Is this gene related to the Congenital Zika syndrome?

Details

Gene description: microcephalin 1 [Source:HGNC Symbol;Acc:6954]

Gene Symbol: MCPH1

Expression Data [Source: SRA Project PRJNA313294]:


 Overexpressed in noninfected

 Overexpressed in infected

Adjusted pvalue: 8.82761e-05

Mean Expression: 1640.11

Representative genomes:

BR6 BR1 BR3 BR4 PF1 BR2 BR5 HT1 MQ1 PR1 CF1 CF2 CF3 UG2 UG3 UG1 zikv-mir-1 zikv-mir-7 zikv-mir-8 zikv-mir-4 zikv-mir-6 zikv-mir-3 zikv-mir-2 zikv-mir-5 zikv-mir-9

OMIM:

  •     251200 / Microcephaly 1, primary, autosomal recessive (MCPH1) /
       Description: A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder. Some MCHP1 patients also present growth retardation, short stature, and misregulated chromosome condensation as indicated by a high number of prophase-like cells detected in routine cytogenetic preparations and poor-quality metaphase G-banding. {ECO:0000269|PubMed:12046007, ECO:0000269|PubMed:15199523, ECO:0000269|PubMed:16211557}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Kegg Disease:

  •     K19403 / Other congenital disorders / Congenital disorders of development / Primary microcephaly / HSA:79648

Transcripts

Transcript ENST00000521175
Length
777
Genome Location
GRCh37:8:6478973:6500891:1
Score
149
Energy
-17.31
Alignment
zikv-mir-2

ENST00000521175
3' ugggUCGUCUUCAGGCCGACCGUUg 5'
   ....|.::|:..|:.|.|||||||.   
5' gagaAATGGGTCTTAGACTGGCAAg 3'
Transcript ENST00000344683
Length
3158
Genome Location
GRCh37:8:6264113:6501144:1
Score
149
Energy
-21.58
Alignment
zikv-mir-3

ENST00000344683
3' agGUG-GUCUCUCUUUAGUGGUGAg 5'
   ..|||.||||...||:.:||||||.   
5' agCACACAGAACAAAGGTACCACTt 3'
Transcript ENST00000344683
Length
3158
Genome Location
GRCh37:8:6264113:6501144:1
Score
146
Energy
-20.11
Alignment
zikv-mir-3

ENST00000344683
3' agGUGGUCUCUCUUUAGUGGUGAg 5'
   ..|:::.||...:..||||||||.   
5' gcCGTTCGAACTGTCTCACCACTt 3'
Transcript ENST00000519221
Length
539
Genome Location
GRCh37:8:6334787:6479192:1
Score
146
Energy
-20.11
Alignment
zikv-mir-3

ENST00000519221
3' agGUGGUCUCUCUUUAGUGGUGAg 5'
   ..|:::.||...:..||||||||.   
5' gcCGTTCGAACTGTCTCACCACTt 3'
Transcript ENST00000519480
Length
2917
Genome Location
GRCh37:8:6264117:6304088:1
Score
149
Energy
-21.58
Alignment
zikv-mir-3

ENST00000519480
3' agGUG-GUCUCUCUUUAGUGGUGAg 5'
   ..|||.||||...||:.:||||||.   
5' agCACACAGAACAAAGGTACCACTt 3'
Transcript ENST00000521129
Length
540
Genome Location
GRCh37:8:6334880:6479142:1
Score
146
Energy
-20.11
Alignment
zikv-mir-3

ENST00000521129
3' agGUGGUCUCUCUUUAGUGGUGAg 5'
   ..|:::.||...:..||||||||.   
5' gcCGTTCGAACTGTCTCACCACTt 3'
Transcript ENST00000522905
Length
2049
Genome Location
GRCh37:8:6264164:6303411:1
Score
149
Energy
-21.58
Alignment
zikv-mir-3

ENST00000522905
3' agGUG-GUCUCUCUUUAGUGGUGAg 5'
   ..|||.||||...||:.:||||||.   
5' agCACACAGAACAAAGGTACCACTt 3'
Transcript ENST00000519480
Length
2917
Genome Location
GRCh37:8:6264117:6304088:1
Score
146
Energy
-19.27
Alignment
zikv-mir-9

ENST00000519480
3' acccaCCUAUCUAUCAGGu 5'
   .....|||||.:||||||.   
5' caaaaGGATAAGTAGTCCa 3'
Transcript ENST00000522905
Length
2049
Genome Location
GRCh37:8:6264164:6303411:1
Score
146
Energy
-19.27
Alignment
zikv-mir-9

ENST00000522905
3' acccaCCUAUCUAUCAGGu 5'
   .....|||||.:||||||.   
5' caaaaGGATAAGTAGTCCa 3'

Literature related to this gene

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Experimental validation

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