Is this gene related to the Congenital Zika syndrome?

Details

Gene description: interferon induced transmembrane protein 3 [Source:HGNC Symbol;Acc:5414]

Gene Symbol: IFITM3

Expression Data [Source: SRA Project PRJNA313294]:


 Overexpressed in noninfected

 Overexpressed in infected

Adjusted pvalue: 0.654413

Mean Expression: 164.006

Representative genomes:

BR6 BR1 BR3 BR4 PF1 BR2 BR5 HT1 MQ1 PR1 CF1 CF2 CF3 UG2 UG3 UG1 zikv-mir-1 zikv-mir-7 zikv-mir-8 zikv-mir-4 zikv-mir-6 zikv-mir-3 zikv-mir-2 zikv-mir-5 zikv-mir-9

Kegg Disease:

  •     K06566 / Musculoskeletal diseases / Skeletal diseases / Osteogenesis imperfecta / HSA:387733

Transcripts

Transcript ENST00000399808
Length
808
Genome Location
GRCh37:11:319669:321050:-1
Score
142
Energy
-19.73
Alignment
zikv-mir-3

ENST00000399808
3' aggugGUCU-CUCUUUAGUGGUGAg 5'
   .....:|||..||:|:.||:||||.   
5' atggaTAGATCAGGAGGCATCACTg 3'
Transcript ENST00000526811
Length
543
Genome Location
GRCh37:11:319773:321340:-1
Score
142
Energy
-19.73
Alignment
zikv-mir-3

ENST00000526811
3' aggugGUCU-CUCUUUAGUGGUGAg 5'
   .....:|||..||:|:.||:||||.   
5' atggaTAGATCAGGAGGCATCACTg 3'
Transcript ENST00000531688
Length
500
Genome Location
GRCh37:11:319746:320683:-1
Score
142
Energy
-19.73
Alignment
zikv-mir-3

ENST00000531688
3' aggugGUCU-CUCUUUAGUGGUGAg 5'
   .....:|||..||:|:.||:||||.   
5' atggaTAGATCAGGAGGCATCACTg 3'
Transcript ENST00000602735
Length
713
Genome Location
GRCh37:11:319773:327537:-1
Score
142
Energy
-19.73
Alignment
zikv-mir-3

ENST00000602735
3' aggugGUCU-CUCUUUAGUGGUGAg 5'
   .....:|||..||:|:.||:||||.   
5' atggaTAGATCAGGAGGCATCACTg 3'

Literature related to this gene

# Ensembl ID Pubmed ID Contributor Additional comments Community Feedback
3 ENSG00000142089 27268505 Gabriel Fernandes - Fiocruz Minas IFIMT3 inhibit Zika virus infection early in the viral life cycle and prevent Zika-virus-induced cell death.
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Experimental validation

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