Is this gene related to the Congenital Zika syndrome?

Details

Gene description: peroxisomal biogenesis factor 6 [Source:HGNC Symbol;Acc:8859]

Gene Symbol: PEX6

Expression Data [Source: SRA Project PRJNA313294]:


 Overexpressed in noninfected

 Overexpressed in infected

Adjusted pvalue: 0.394129

Mean Expression: 1356.65

Representative genomes:

BR6 BR1 BR3 BR4 PF1 BR2 BR5 HT1 MQ1 PR1 CF1 CF2 CF3 UG2 UG3 UG1 zikv-mir-1 zikv-mir-7 zikv-mir-8 zikv-mir-4 zikv-mir-6 zikv-mir-3 zikv-mir-2 zikv-mir-5 zikv-mir-9

OMIM:

  •     614862 / Peroxisome biogenesis disorder complementation group 4 (PBD-CG4) /
       Description: A peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS). {ECO:0000269|PubMed:19105186, ECO:0000269|PubMed:26387595}. Note=The disease is caused by mutations affecting the gene represented in this entry.;
  •     614863 / Peroxisome biogenesis disorder 4B (PBD4B) /
       Description: A peroxisome biogenesis disorder that includes neonatal adrenoleukodystrophy (NALD) and infantile Refsum disease (IRD), two milder manifestations of the Zellweger disease spectrum. The clinical course of patients with the NALD and IRD presentation is variable and may include developmental delay, hypotonia, liver dysfunction, sensorineural hearing loss, retinal dystrophy and vision impairment. Children with the NALD presentation may reach their teens, while patients with the IRD presentation may reach adulthood. The clinical conditions are often slowly progressive in particular with respect to loss of hearing and vision. The biochemical abnormalities include accumulation of phytanic acid, very long chain fatty acids (VLCFA), di- and trihydroxycholestanoic acid and pipecolic acid. {ECO:0000269|PubMed:11355018}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Kegg Disease:

  •     K13339 / Congenital disorders of metabolism / Peroxisomal diseases / Peroxisome biogenesis disorder / HSA:5190
  •     K13339 / Congenital disorders of metabolism / Peroxisomal diseases / Zellweger syndrome (ZS) / HSA:5190

Transcripts

Transcript ENST00000244546
Length
2696
Genome Location
GRCh37:6:42932073:42946888:-1
Score
147
Energy
-16.39
Alignment
zikv-mir-1

ENST00000244546
3' uugAAGGGGAUUUUUACAAUGUGUca 5'
   ...||:.||.|:|:|.||||||||..   
5' ccaTTTGCC-AGAGA-GTTACACAtc 3'
Transcript ENST00000244546
Length
2696
Genome Location
GRCh37:6:42932073:42946888:-1
Score
147
Energy
-18.71
Alignment
zikv-mir-1

ENST00000244546
3' uuGAAGGG---GAUUUUUACAAUGUGUCa 5'
   ..|||.||...|||:|.:.|.|:|||||.   
5' tcCTTGCCGAGCTAGATGGGCTGCACAGc 3'
Transcript ENST00000304611
Length
3478
Genome Location
GRCh37:6:42931608:42946958:-1
Score
147
Energy
-16.39
Alignment
zikv-mir-1

ENST00000304611
3' uugAAGGGGAUUUUUACAAUGUGUca 5'
   ...||:.||.|:|:|.||||||||..   
5' ccaTTTGCC-AGAGA-GTTACACAtc 3'
Transcript ENST00000304611
Length
3478
Genome Location
GRCh37:6:42931608:42946958:-1
Score
147
Energy
-18.71
Alignment
zikv-mir-1

ENST00000304611
3' uuGAAGGG---GAUUUUUACAAUGUGUCa 5'
   ..|||.||...|||:|.:.|.|:|||||.   
5' tcCTTGCCGAGCTAGATGGGCTGCACAGc 3'
Transcript ENST00000244546
Length
2696
Genome Location
GRCh37:6:42932073:42946888:-1
Score
145
Energy
-31.28
Alignment
zikv-mir-8

ENST00000244546
3' ucGGGUCCAC-CACGCGCCag 5'
   ..||::||||.|.||||||..   
5' ggCCTGGGTGCGGGCGCGGgc 3'
Transcript ENST00000244546
Length
2696
Genome Location
GRCh37:6:42932073:42946888:-1
Score
141
Energy
-24.42
Alignment
zikv-mir-8

ENST00000244546
3' ucGGGUCCAC--CACGCGCCag 5'
   ..|||||.||..|.||||||..   
5' tcCCCAGCTGACGGGCGCGGac 3'
Transcript ENST00000304611
Length
3478
Genome Location
GRCh37:6:42931608:42946958:-1
Score
145
Energy
-31.28
Alignment
zikv-mir-8

ENST00000304611
3' ucGGGUCCAC-CACGCGCCag 5'
   ..||::||||.|.||||||..   
5' ggCCTGGGTGCGGGCGCGGgc 3'
Transcript ENST00000304611
Length
3478
Genome Location
GRCh37:6:42931608:42946958:-1
Score
141
Energy
-24.42
Alignment
zikv-mir-8

ENST00000304611
3' ucGGGUCCAC--CACGCGCCag 5'
   ..|||||.||..|.||||||..   
5' tcCCCAGCTGACGGGCGCGGac 3'

Literature related to this gene

# Ensembl ID Pubmed ID Contributor Additional comments Community Feedback
1 ENSG00000124587 26387595 Gabriel Fernandes - Fiocruz Mutations in this gene lead to Neonatal adrenoleukodystrophy, which is the degeneration of white matter in brain.
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Experimental validation

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