Is this gene related to the Congenital Zika syndrome?

Details

Gene description: cyclin-dependent kinase 6 [Source:HGNC Symbol;Acc:1777]

Gene Symbol: CDK6

Expression Data [Source: SRA Project PRJNA313294]:


 Overexpressed in noninfected

 Overexpressed in infected

Adjusted pvalue: 0.00683249

Mean Expression: 16604.5

Representative genomes:

BR6 BR1 BR3 BR4 PF1 BR2 BR5 HT1 MQ1 PR1 CF1 CF2 CF3 UG2 UG3 UG1 zikv-mir-1 zikv-mir-7 zikv-mir-8 zikv-mir-4 zikv-mir-6 zikv-mir-3 zikv-mir-2 zikv-mir-5 zikv-mir-9

OMIM:

  •     616080 / Microcephaly 12, primary, autosomal recessive (MCPH12) /
       Description: A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. {ECO:0000269|PubMed:23918663}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Kegg Disease:

Transcripts

Transcript ENST00000265734
Length
11612
Genome Location
GRCh37:7:92234235:92463231:-1
Score
158
Energy
-21.61
Alignment
zikv-mir-1

ENST00000265734
3' uuGAAGGGGAUUUUUACAAUGUGUCa 5'
   ..||||:|:|.....||.|||||||.   
5' tgCTTCTCTTTTCTCTG-TACACAGa 3'
Transcript ENST00000265734
Length
11612
Genome Location
GRCh37:7:92234235:92463231:-1
Score
151
Energy
-20.25
Alignment
zikv-mir-1

ENST00000265734
3' uugaagGGGAUUUUU-ACAAUGUGUCa 5'
   ......:::|:::||.||||:|||||.   
5' caggcaTTTTGGGAACTGTTGCACAGg 3'
Transcript ENST00000265734
Length
11612
Genome Location
GRCh37:7:92234235:92463231:-1
Score
142
Energy
-21.00
Alignment
zikv-mir-3

ENST00000265734
3' agguGGUCUCUCUUUAGUGGUGAg 5'
   ....|:||.|...::.|||||||.   
5' ctgtCTAG-GCCTGGCCACCACTc 3'
Transcript ENST00000265734
Length
11612
Genome Location
GRCh37:7:92234235:92463231:-1
Score
157
Energy
-25.02
Alignment
zikv-mir-5

ENST00000265734
3' ggaUGACGUCGG-UA-CCCAGGUc 5'
   ...||.|::|||.:|.|||||||.   
5' accACAGTGGCCTGTCGGGTCCAc 3'
Transcript ENST00000265734
Length
11612
Genome Location
GRCh37:7:92234235:92463231:-1
Score
145
Energy
-18.59
Alignment
zikv-mir-5

ENST00000265734
3' ggaugacGUCGGUACCCAGGUc 5'
   .......|||..|.|||||||.   
5' gtaaaaaCAG-AAGGGGTCCAa 3'
Transcript ENST00000265734
Length
11612
Genome Location
GRCh37:7:92234235:92463231:-1
Score
145
Energy
-16.88
Alignment
zikv-mir-6

ENST00000265734
3' uaauuCCUCAUCAACAACAUAc 5'
   .....||.||||||||||.||.   
5' ccatcGGTGTAGTTGTTGCATt 3'

Literature related to this gene

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Experimental validation

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