Is this gene related to the Congenital Zika syndrome?

Details

Gene description: tumor protein p63 [Source:HGNC Symbol;Acc:15979]

Gene Symbol: TP63

Expression Data [Source: SRA Project PRJNA313294]:


 Overexpressed in noninfected

 Overexpressed in infected

Adjusted pvalue:

Mean Expression: 6.30112

Representative genomes:

BR6 BR1 BR3 BR4 PF1 BR2 BR5 HT1 MQ1 PR1 CF1 CF2 CF3 UG2 UG3 UG1 zikv-mir-1 zikv-mir-7 zikv-mir-8 zikv-mir-4 zikv-mir-6 zikv-mir-3 zikv-mir-2 zikv-mir-5 zikv-mir-9

OMIM:

  •     103285 / Acro-dermato-ungual-lacrimal-tooth syndrome (ADULT syndrome) /
       Description: A form of ectodermal dysplasia. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ADULT syndrome involves ectrodactyly, syndactyly, finger- and toenail dysplasia, hypoplastic breasts and nipples, intensive freckling, lacrimal duct atresia, frontal alopecia, primary hypodontia and loss of permanent teeth. ADULT syndrome differs significantly from EEC3 syndrome by the absence of facial clefting. {ECO:0000269|PubMed:11929852}. Note=The disease is caused by mutations affecting the gene represented in this entry.;
  •     106260 / Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) /
       Description: An autosomal dominant condition characterized by congenital ectodermal dysplasia with coarse, wiry, sparse hair, dystrophic nails, slight hypohidrosis, scalp infections, ankyloblepharon filiform adnatum, maxillary hypoplasia, hypodontia and cleft lip/palate. {ECO:0000269|PubMed:11159940}. Note=The disease is caused by mutations affecting the gene represented in this entry.;
  •     129400 / Ectodermal dysplasia, Rapp-Hodgkin type (EDRH) /
       Description: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Characterized by the combination of anhidrotic ectodermal dysplasia, cleft lip, and cleft palate. The clinical syndrome is comprised of a characteristic facies (narrow nose and small mouth), wiry, slow-growing, and uncombable hair, sparse eyelashes and eyebrows, obstructed lacrimal puncta/epiphora, bilateral stenosis of external auditory canals, microsomia, hypodontia, cone-shaped incisors, enamel hypoplasia, dystrophic nails, and cleft lip/cleft palate. {ECO:0000269|PubMed:12766194, ECO:0000269|PubMed:12939657, ECO:0000269|PubMed:15200513, ECO:0000269|PubMed:16740912}. Note=The disease is caused by mutations affecting the gene represented in this entry.;
  •     603543 / Limb-mammary syndrome (LMS) /
       Description: Characterized by ectrodactyly, cleft palate and mammary-gland abnormalities. {ECO:0000269|PubMed:11462173}. Note=The disease is caused by mutations affecting the gene represented in this entry.;
  •     604292 / Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3) /
       Description: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal dominant syndrome characterized by ectrodactyly of hands and feet, ectodermal dysplasia and facial clefting. {ECO:0000269|PubMed:10535733, ECO:0000269|PubMed:10839977, ECO:0000269|PubMed:11462173, ECO:0000269|PubMed:12838557}. Note=The disease is caused by mutations affecting the gene represented in this entry.;
  •     605289 / Split-hand/foot malformation 4 (SHFM4) /
       Description: A limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting. {ECO:0000269|PubMed:10839977, ECO:0000269|PubMed:11462173}. Note=The disease is caused by mutations affecting the gene represented in this entry.;

Kegg Disease:

  •     K10149 / Musculoskeletal diseases / Skeletal diseases / Ectrodactyly-ectodermal dysplasia cleft-palate syndrome (EEC syndrome) / HSA:8626
  •     K10149 / Musculoskeletal diseases / Skeletal diseases / Limb-mammary syndrome / HSA:8626
  •     K10149 / Musculoskeletal diseases / Skeletal diseases / ADULT syndrome / HSA:8626
  •     K10149 / Musculoskeletal diseases / Skeletal diseases / Split-hand/foot malformation (SHFM) / HSA:8626
  •     K10149 / Skin diseases / Skin and soft tissue diseases / Ectrodactyly-ectodermal dysplasia cleft-palate syndrome (EEC syndrome) / HSA:8626
  •     K10149 / Skin diseases / Skin and soft tissue diseases / ADULT syndrome / HSA:8626
  •     K10149 / Skin diseases / Skin and soft tissue diseases / Limb-mammary syndrome / HSA:8626
  •     K10149 / Other congenital disorders / Congenital disorders of development / Isolated orofacial clefts / HSA:8626
  •     K10149 / Other congenital disorders / Congenital disorders of development / Ankyloblepharon-ctodermal defects-cleft lip/palate (AEC) syndrome and Rapp-Hodgkin syndrome / HSA:8626

Transcripts

Transcript ENST00000264731
Length
4909
Genome Location
GRCh37:3:189349216:189615068:1
Score
150
Energy
-15.18
Alignment
zikv-mir-1

ENST00000264731
3' uuGAAGGGGAUUUUUACAAUGUGUCa 5'
   ..|||:.:.|..|.||..|||||||.   
5' ggCTTTATATCTATAT-ATACACAGg 3'
Transcript ENST00000382063
Length
4654
Genome Location
GRCh37:3:189349216:189615068:1
Score
150
Energy
-15.18
Alignment
zikv-mir-1

ENST00000382063
3' uuGAAGGGGAUUUUUACAAUGUGUCa 5'
   ..|||:.:.|..|.||..|||||||.   
5' ggCTTTATATCTATAT-ATACACAGg 3'
Transcript ENST00000486398
Length
546
Genome Location
GRCh37:3:189349205:189456685:1
Score
150
Energy
-15.18
Alignment
zikv-mir-1

ENST00000486398
3' uuGAAGGGGAUUUUUACAAUGUGUCa 5'
   ..|||:.:.|..|.||..|||||||.   
5' ggCTTTATATCTATAT-ATACACAGg 3'
Transcript ENST00000264731
Length
4909
Genome Location
GRCh37:3:189349216:189615068:1
Score
143
Energy
-18.37
Alignment
zikv-mir-2

ENST00000264731
3' ugggUCGUCUUCAGG--CC-----GACCGUUg 5'
   ....||||..|.|||..||.....|||||||.   
5' attgAGCATTACTCCATGGATGATCTGGCAAg 3'
Transcript ENST00000320472
Length
2032
Genome Location
GRCh37:3:189349277:189612491:1
Score
143
Energy
-20.73
Alignment
zikv-mir-2

ENST00000320472
3' uggGUCGU--CUUCAG--GCC--GACCGUUg 5'
   ...::|||..|:||.|..|.|..|||||||.   
5' tgaTGGCATGGGAGCCAACAGATCTGGCAAg 3'
Transcript ENST00000354600
Length
4668
Genome Location
GRCh37:3:189507449:189615057:1
Score
143
Energy
-18.37
Alignment
zikv-mir-2

ENST00000354600
3' ugggUCGUCUUCAGG--CC-----GACCGUUg 5'
   ....||||..|.|||..||.....|||||||.   
5' attgAGCATTACTCCATGGATGATCTGGCAAg 3'
Transcript ENST00000382063
Length
4654
Genome Location
GRCh37:3:189349216:189615068:1
Score
143
Energy
-18.37
Alignment
zikv-mir-2

ENST00000382063
3' ugggUCGUCUUCAGG--CC-----GACCGUUg 5'
   ....||||..|.|||..||.....|||||||.   
5' attgAGCATTACTCCATGGATGATCTGGCAAg 3'
Transcript ENST00000392460
Length
1668
Genome Location
GRCh37:3:189349305:189612010:1
Score
159
Energy
-24.03
Alignment
zikv-mir-2

ENST00000392460
3' uggGUCGUCUUCAGGCC--GACCGUUg 5'
   ...|||||...|||.||..|||||||.   
5' ttgCAGCA-TTGTCAGGATCTGGCAAg 3'
Transcript ENST00000392461
Length
1251
Genome Location
GRCh37:3:189507590:189612020:1
Score
143
Energy
-20.73
Alignment
zikv-mir-2

ENST00000392461
3' uggGUCGU--CUUCAG--GCC--GACCGUUg 5'
   ...::|||..|:||.|..|.|..|||||||.   
5' tgaTGGCATGGGAGCCAACAGATCTGGCAAg 3'
Transcript ENST00000392463
Length
1386
Genome Location
GRCh37:3:189507590:189612010:1
Score
159
Energy
-24.03
Alignment
zikv-mir-2

ENST00000392463
3' uggGUCGUCUUCAGGCC--GACCGUUg 5'
   ...|||||...|||.||..|||||||.   
5' ttgCAGCA-TTGTCAGGATCTGGCAAg 3'
Transcript ENST00000440651
Length
2031
Genome Location
GRCh37:3:189349305:189612291:1
Score
143
Energy
-18.37
Alignment
zikv-mir-2

ENST00000440651
3' ugggUCGUCUUCAGG--CC-----GACCGUUg 5'
   ....||||..|.|||..||.....|||||||.   
5' attgAGCATTACTCCATGGATGATCTGGCAAg 3'
Transcript ENST00000449992
Length
1506
Genome Location
GRCh37:3:189507590:189612291:1
Score
143
Energy
-18.37
Alignment
zikv-mir-2

ENST00000449992
3' ugggUCGUCUUCAGG--CC-----GACCGUUg 5'
   ....||||..|.|||..||.....|||||||.   
5' attgAGCATTACTCCATGGATGATCTGGCAAg 3'
Transcript ENST00000456148
Length
1749
Genome Location
GRCh37:3:189507590:189612291:1
Score
143
Energy
-18.37
Alignment
zikv-mir-2

ENST00000456148
3' ugggUCGUCUUCAGG--CC-----GACCGUUg 5'
   ....||||..|.|||..||.....|||||||.   
5' attgAGCATTACTCCATGGATGATCTGGCAAg 3'
Transcript ENST00000434928
Length
676
Genome Location
GRCh37:3:189507464:189582057:1
Score
141
Energy
-19.55
Alignment
zikv-mir-5

ENST00000434928
3' ggauGACGUCG-GUACCCAGGUc 5'
   ....||.||.|.|.|||||:||.   
5' caacCTCCACCTCCTGGGTTCAa 3'
Transcript ENST00000418709
Length
2810
Genome Location
GRCh37:3:189349277:189599285:1
Score
158
Energy
-13.62
Alignment
zikv-mir-6

ENST00000418709
3' uaAUUCCUCAUCAACAACAUAc 5'
   ..|||.|.||:..||||||||.   
5' ttTAA-GTGTGTGTGTTGTATt 3'
Transcript ENST00000437221
Length
2500
Genome Location
GRCh37:3:189507590:189599285:1
Score
158
Energy
-13.62
Alignment
zikv-mir-6

ENST00000437221
3' uaAUUCCUCAUCAACAACAUAc 5'
   ..|||.|.||:..||||||||.   
5' ttTAA-GTGTGTGTGTTGTATt 3'
Transcript ENST00000264731
Length
4909
Genome Location
GRCh37:3:189349216:189615068:1
Score
145
Energy
-17.09
Alignment
zikv-mir-7

ENST00000264731
3' acguucuguccGUCAGAGGg 5'
   ...........||||||||.   
5' agacctcaataCAGTCTCCa 3'
Transcript ENST00000320472
Length
2032
Genome Location
GRCh37:3:189349277:189612491:1
Score
145
Energy
-17.09
Alignment
zikv-mir-7

ENST00000320472
3' acguucuguccGUCAGAGGg 5'
   ...........||||||||.   
5' agacctcaataCAGTCTCCa 3'
Transcript ENST00000354600
Length
4668
Genome Location
GRCh37:3:189507449:189615057:1
Score
145
Energy
-17.09
Alignment
zikv-mir-7

ENST00000354600
3' acguucuguccGUCAGAGGg 5'
   ...........||||||||.   
5' agacctcaataCAGTCTCCa 3'
Transcript ENST00000382063
Length
4654
Genome Location
GRCh37:3:189349216:189615068:1
Score
145
Energy
-17.09
Alignment
zikv-mir-7

ENST00000382063
3' acguucuguccGUCAGAGGg 5'
   ...........||||||||.   
5' agacctcaataCAGTCTCCa 3'
Transcript ENST00000392460
Length
1668
Genome Location
GRCh37:3:189349305:189612010:1
Score
145
Energy
-17.09
Alignment
zikv-mir-7

ENST00000392460
3' acguucuguccGUCAGAGGg 5'
   ...........||||||||.   
5' agacctcaataCAGTCTCCa 3'
Transcript ENST00000392461
Length
1251
Genome Location
GRCh37:3:189507590:189612020:1
Score
145
Energy
-17.09
Alignment
zikv-mir-7

ENST00000392461
3' acguucuguccGUCAGAGGg 5'
   ...........||||||||.   
5' agacctcaataCAGTCTCCa 3'
Transcript ENST00000392463
Length
1386
Genome Location
GRCh37:3:189507590:189612010:1
Score
145
Energy
-17.09
Alignment
zikv-mir-7

ENST00000392463
3' acguucuguccGUCAGAGGg 5'
   ...........||||||||.   
5' agacctcaataCAGTCTCCa 3'
Transcript ENST00000440651
Length
2031
Genome Location
GRCh37:3:189349305:189612291:1
Score
145
Energy
-17.09
Alignment
zikv-mir-7

ENST00000440651
3' acguucuguccGUCAGAGGg 5'
   ...........||||||||.   
5' agacctcaataCAGTCTCCa 3'
Transcript ENST00000449992
Length
1506
Genome Location
GRCh37:3:189507590:189612291:1
Score
145
Energy
-17.09
Alignment
zikv-mir-7

ENST00000449992
3' acguucuguccGUCAGAGGg 5'
   ...........||||||||.   
5' agacctcaataCAGTCTCCa 3'
Transcript ENST00000456148
Length
1749
Genome Location
GRCh37:3:189507590:189612291:1
Score
145
Energy
-17.09
Alignment
zikv-mir-7

ENST00000456148
3' acguucuguccGUCAGAGGg 5'
   ...........||||||||.   
5' agacctcaataCAGTCTCCa 3'

Literature related to this gene

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Experimental validation

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