Is this gene related to the Congenital Zika syndrome?

Details

Gene description: CREB binding protein [Source:HGNC Symbol;Acc:2348]

Gene Symbol: CREBBP

Expression Data [Source: SRA Project PRJNA313294]:


 Overexpressed in noninfected

 Overexpressed in infected

Adjusted pvalue: 3.59542e-10

Mean Expression: 12455.2

Representative genomes:

BR6 BR1 BR3 BR4 PF1 BR2 BR5 HT1 MQ1 PR1 CF1 CF2 CF3 UG2 UG3 UG1 zikv-mir-1 zikv-mir-7 zikv-mir-8 zikv-mir-4 zikv-mir-6 zikv-mir-3 zikv-mir-2 zikv-mir-5 zikv-mir-9

OMIM:

  •     180849 / Rubinstein-Taybi syndrome 1 (RSTS1) /
       Description: A disorder characterized by craniofacial abnormalities, postnatal growth deficiency, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies. {ECO:0000269|PubMed:11331617, ECO:0000269|PubMed:12114483, ECO:0000269|PubMed:12566391, ECO:0000269|PubMed:15706485, ECO:0000269|PubMed:20684013, ECO:0000269|PubMed:25388907}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Kegg Disease:

  •     K04498 / Musculoskeletal diseases / Skeletal diseases / Rubinstein-Taybi syndrome / HSA:1387
  •     K04498 / Musculoskeletal diseases / Skeletal diseases / Rubinstein-Taybi syndrome / HSA:2033

Transcripts

Transcript ENST00000262367
Length
10803
Genome Location
GRCh37:16:3775055:3930727:-1
Score
152
Energy
-22.26
Alignment
zikv-mir-1

ENST00000262367
3' uuGAAGGGGAUUUUUACAAUGUGUCa 5'
   ..:|||:.:.|:||:||||.|||||.   
5' caTTTCTGTGAGAAGTGTTTCACAGa 3'
Transcript ENST00000382070
Length
7598
Genome Location
GRCh37:16:3777540:3930121:-1
Score
152
Energy
-22.26
Alignment
zikv-mir-1

ENST00000382070
3' uuGAAGGGGAUUUUUACAAUGUGUCa 5'
   ..:|||:.:.|:||:||||.|||||.   
5' caTTTCTGTGAGAAGTGTTTCACAGa 3'
Transcript ENST00000573517
Length
716
Genome Location
GRCh37:16:3789447:3801809:-1
Score
152
Energy
-22.26
Alignment
zikv-mir-1

ENST00000573517
3' uuGAAGGGGAUUUUUACAAUGUGUCa 5'
   ..:|||:.:.|:||:||||.|||||.   
5' caTTTCTGTGAGAAGTGTTTCACAGa 3'
Transcript ENST00000576720
Length
3578
Genome Location
GRCh37:16:3781912:3793469:-1
Score
145
Energy
-14.40
Alignment
zikv-mir-1

ENST00000576720
3' uugaAGGGGAUUUUUA-CAAUGUGUca 5'
   ....|||:.|||||||..||:||||..   
5' tgtaTCCTATAAAAATATTTGCACAta 3'
Transcript ENST00000262367
Length
10803
Genome Location
GRCh37:16:3775055:3930727:-1
Score
153
Energy
-28.48
Alignment
zikv-mir-2

ENST00000262367
3' uggGUCGUC-UUCAGGCCGACCGUUg 5'
   ...||..||.||||..|||||||:|.   
5' gcaCAAAAGCAAGTGGGGCTGGCGAc 3'
Transcript ENST00000262367
Length
10803
Genome Location
GRCh37:16:3775055:3930727:-1
Score
142
Energy
-28.26
Alignment
zikv-mir-2

ENST00000262367
3' ugGGUCGUCUU-CAGGCCGACCGUug 5'
   ..||:|::.||.|...||||||||..   
5' caCCGGTGTAAGGAAAGGCTGGCAcg 3'
Transcript ENST00000262367
Length
10803
Genome Location
GRCh37:16:3775055:3930727:-1
Score
143
Energy
-25.78
Alignment
zikv-mir-2

ENST00000262367
3' ugGGUCGUCUUCAGGCCGACCGUug 5'
   ..|||...|:||.|..|||||||..   
5' caCCACGTGGAGACGCGCTGGCAct 3'
Transcript ENST00000382070
Length
7598
Genome Location
GRCh37:16:3777540:3930121:-1
Score
143
Energy
-25.78
Alignment
zikv-mir-2

ENST00000382070
3' ugGGUCGUCUUCAGGCCGACCGUug 5'
   ..|||...|:||.|..|||||||..   
5' caCCACGTGGAGACGCGCTGGCAct 3'
Transcript ENST00000382070
Length
7598
Genome Location
GRCh37:16:3777540:3930121:-1
Score
153
Energy
-28.48
Alignment
zikv-mir-2

ENST00000382070
3' uggGUCGUC-UUCAGGCCGACCGUUg 5'
   ...||..||.||||..|||||||:|.   
5' gcaCAAAAGCAAGTGGGGCTGGCGAc 3'
Transcript ENST00000382070
Length
7598
Genome Location
GRCh37:16:3777540:3930121:-1
Score
142
Energy
-28.26
Alignment
zikv-mir-2

ENST00000382070
3' ugGGUCGUCUU-CAGGCCGACCGUug 5'
   ..||:|::.||.|...||||||||..   
5' caCCGGTGTAAGGAAAGGCTGGCAcg 3'
Transcript ENST00000572134
Length
846
Genome Location
GRCh37:16:3823637:3830868:-1
Score
142
Energy
-28.26
Alignment
zikv-mir-2

ENST00000572134
3' ugGGUCGUCUU-CAGGCCGACCGUug 5'
   ..||:|::.||.|...||||||||..   
5' caCCGGTGTAAGGAAAGGCTGGCAcg 3'
Transcript ENST00000262367
Length
10803
Genome Location
GRCh37:16:3775055:3930727:-1
Score
144
Energy
-15.46
Alignment
zikv-mir-3

ENST00000262367
3' agGUGGUCUCUCUUUAGUGGUGag 5'
   ..||.|.|||.|.||.||||||..   
5' tgCAAC-GAGTGCAAGCACCACgt 3'
Transcript ENST00000262367
Length
10803
Genome Location
GRCh37:16:3775055:3930727:-1
Score
148
Energy
-25.87
Alignment
zikv-mir-3

ENST00000262367
3' agGUGGUCUCU-CUU-UAGUGGUGAg 5'
   ..||.|||:||.|||.||:|:||||.   
5' aaCAGCAGGGATGAATATTATCACTt 3'
Transcript ENST00000262367
Length
10803
Genome Location
GRCh37:16:3775055:3930727:-1
Score
173
Energy
-27.16
Alignment
zikv-mir-3

ENST00000262367
3' agGUGGUCUCUCU-UUAGUGGUGAg 5'
   ..|.||||.||.|.|:||||||||.   
5' ccCTCCAGTGACACAGTCACCACTg 3'
Transcript ENST00000382070
Length
7598
Genome Location
GRCh37:16:3777540:3930121:-1
Score
173
Energy
-27.16
Alignment
zikv-mir-3

ENST00000382070
3' agGUGGUCUCUCU-UUAGUGGUGAg 5'
   ..|.||||.||.|.|:||||||||.   
5' ccCTCCAGTGACACAGTCACCACTg 3'
Transcript ENST00000382070
Length
7598
Genome Location
GRCh37:16:3777540:3930121:-1
Score
144
Energy
-15.46
Alignment
zikv-mir-3

ENST00000382070
3' agGUGGUCUCUCUUUAGUGGUGag 5'
   ..||.|.|||.|.||.||||||..   
5' tgCAAC-GAGTGCAAGCACCACgt 3'
Transcript ENST00000382070
Length
7598
Genome Location
GRCh37:16:3777540:3930121:-1
Score
148
Energy
-25.87
Alignment
zikv-mir-3

ENST00000382070
3' agGUGGUCUCU-CUU-UAGUGGUGAg 5'
   ..||.|||:||.|||.||:|:||||.   
5' aaCAGCAGGGATGAATATTATCACTt 3'
Transcript ENST00000572134
Length
846
Genome Location
GRCh37:16:3823637:3830868:-1
Score
148
Energy
-25.87
Alignment
zikv-mir-3

ENST00000572134
3' agGUGGUCUCU-CUU-UAGUGGUGAg 5'
   ..||.|||:||.|||.||:|:||||.   
5' aaCAGCAGGGATGAATATTATCACTt 3'
Transcript ENST00000576720
Length
3578
Genome Location
GRCh37:16:3781912:3793469:-1
Score
150
Energy
-16.35
Alignment
zikv-mir-3

ENST00000576720
3' agguGGUCUCUCUUUAGUGGUGAg 5'
   ....|||.|.|..|:.|||||||.   
5' ttatCCAAAAATCAG-CACCACTg 3'
Transcript ENST00000262367
Length
10803
Genome Location
GRCh37:16:3775055:3930727:-1
Score
145
Energy
-15.47
Alignment
zikv-mir-7

ENST00000262367
3' acguucuguccGUCAGAGGg 5'
   ...........||||||||.   
5' cagcccctgtcCAGTCTCCa 3'
Transcript ENST00000382070
Length
7598
Genome Location
GRCh37:16:3777540:3930121:-1
Score
145
Energy
-15.47
Alignment
zikv-mir-7

ENST00000382070
3' acguucuguccGUCAGAGGg 5'
   ...........||||||||.   
5' cagcccctgtcCAGTCTCCa 3'
Transcript ENST00000262367
Length
10803
Genome Location
GRCh37:16:3775055:3930727:-1
Score
141
Energy
-20.94
Alignment
zikv-mir-8

ENST00000262367
3' ucgGGUCCACCACGCGCCag 5'
   ...::|.||||.||||||..   
5' tcaTTAAGTGGGGCGCGGgg 3'

Literature related to this gene

# Ensembl ID Pubmed ID Contributor Additional comments Community Feedback
2 ENSG00000005339 25599811 Gabriel Fernandes - Fiocruz RSTS is primarily characterized by delayed growth in height and weight, microcephaly, dysmorphic facial features, and broad thumbs and big toe. It has been shown that mutations in the genes encoding the cyclic-AMP-regulated enhancer binding protein (CREBBP) contributed to the development of RSTS.
Add publication

Experimental validation

Add publication